CLINICAL STUDIES ON THE FOLLOWING INGREDIENTS:
Saw Palmetto And Hair Loss
Treatment of male androgenetic alopecia with topical products containing Serenoa repens extract* https://pubmed.ncbi.nlm.nih.gov/26010505/
Background/objectives: Male androgenetic alopecia (AGA) is a common hair problem. Serenoa repens extract has been shown to inhibit both types of 5-α reductase and, when taken orally, has been shown to increase hair growth in AGA patients. The aim of this study was to assess the efficacy of topical products containing S. repens extract for the treatment of male AGA.
Methods: This was a pilot, prospective, open, within-subject comparison limited to 24 weeks using no placebo controls. In all, 50 male volunteers aged between 20 and 50 years received topical S. repens products for 24 weeks. The primary end-point was a hair count in an area of 2.54 cm(2) at week 24. Secondary end-points included hair restoration, investigators’ photographic assessment, patients’ evaluation and discovering adverse events.
Results: The average hair count and terminal hair count increased at weeks 12 and 24 compared to baseline. Some of these positive results levelled off at week 24, presumably because the concentrated topical product containing S. repens extract was stopped after 4 weeks. The patients were satisfied with the products and the side-effects were limited.
Serenoa Repens: Does It have Any Role in the Management of Androgenetic Alopecia?* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840915/
Serenoa repens is one among the many naturally occurring 5 alpha reductase (5aR) inhibitors which has gained popularity as a magical remedy for androgenetic alopecia. It is widely advertised on the web and sold by direct marketing. Used as a self-medication, there is a risk of missing the early detection of prostate cancer. There is little evidence to support its efficacy, warranting larger clinical trials on androgenetic alopecia.
A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia* https://pubmed.ncbi.nlm.nih.gov/12006122/
Background: Androgenetic alopecia (AGA) is characterized by the structural miniaturization of androgen-sensitive hair follicles in susceptible individuals and is anatomically defined within a given pattern of the scalp. Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic hyperplasia (BPH). Furthermore, AGA has also been shown to be responsive to drugs and agents used to treat BPH. Of note, certain botanical compounds have previously demonstrated efficacy against BPH. Here, we report the first example of a placebo-controlled, double-blind study undertaken in order to examine the benefit of these botanical substances in the treatment of AGA.
Objectives: The goal of this study was to test botanically derived 5AR inhibitors, specifically the liposterolic extract of Serenoa repens (LSESr) and beta-sitosterol, in the treatment of AGA.
Results: The results of this pilot study showed a highly positive response to treatment. The blinded investigative staff assessment report showed that 60% of (6/10) study subjects dosed with the active study formulation were rated as improved at the final visit.
Ashwagandha Root And Hair Loss
A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults* https://pubmed.ncbi.nlm.nih.gov/23439798/
Background: Stress is a state of mental or emotional strain or tension, which can lead to underperformance and adverse clinical conditions. Adaptogens are herbs that help in combating stress. Ayurvedic classical texts, animal studies and clinical studies describe Ashwagandha as a safe and effective adaptogen.
Results: The treatment group that was given the high-concentration full-spectrum Ashwagandha root extract exhibited a significant reduction (P<0.0001) in scores on all the stress-assessment scales on Day 60, relative to the placebo group. The serum cortisol levels were substantially reduced (P=0.0006) in the Ashwagandha group, relative to the placebo group. The adverse effects were mild in nature and were comparable in both the groups. No serious adverse events were reported.
HKU Study on Stem Cell and Aging: revealing anti-aging genetic mechanism* https://www.hku.hk/press/press-releases/detail/9025.html
Abstract: Resveratrol activates longevity protein SIRT1 through Lamin A
The researchers tested the effects of resveratrol, a substance which has been claimed to be effective for anti-aging, on stem cells in HGPS mice and got exciting results that resveratrol protects stem cells but not somatic cells. The study further revealed that resveratrol itself cannot activate longevity protein SIRT1. It increases the binding between Lamin A and SIRT1, therefore enhancing Lamin A-mediated SIRT1 activation. Enhancing SIRT1 activity by resveratrol could restore stem cells, delay the onset of aging, improve the general health conditions and extend lifespan by 30% in progerial mice. This suggests that targeting on SIRT1 activity would likely provide a novel therapeutic strategy for HGPS and aging-associated degenerative diseases.
The current study demonstrates that targeting and preventing stem cells from decline would likely delay the onset of HGPS as well as other degenerative diseases. The study provides a therapeutic strategy in restoring stem cells and extending healthy lifespan by targeting on the longevity protein SIRT1. This may have a profound impact on the elderly societies such as Hong Kong.
Vitamin D and Hair Loss
Does D matter? The role of vitamin D in hair disorders and hair follicle cycling* https://pubmed.ncbi.nlm.nih.gov/20178699/
Background: The role of vitamin D in the proliferation and differentiation of keratinocytes is well known within the field of dermatology.
Objective: We sought to evaluate the role that vitamin D and the vitamin D receptor play in the hair cycle and assess how this can be clinically applied to the treatment of hair disorders.
Results: The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood.